HBOT provides 100% oxygen under two - to three -fold atmospheric pressure can produce arterial oxygen tension of 2000 mmHg or more, and tissue oxygen tension of about 400 mmHg, concentration needed to stimulate and support wound healing.
Increased inmunologic response :
HBOT plays a role antioxidant, increased oxygen tisular in blood cells and inmunologic system.
HBOT has several specific biological actions which can enhance wound healing processes :
The physiological benefits of HBOT are improved oxygenation of threatened margins of wounds, generation of granulation tissue, enhanced phagocytosis and killing of select organisms, enhanced antibiotic penetration of some organisms by antibiotics whose trans-membrane transport is oxygen-dependent, and improved wound healing with increased rate of fibroblast collagen production to support capillary angiogenesis.
Once spread of the necrotic process has been halted, HBOT may promote healing by stimulating angiogenesis and granulation tissue formation, as in other condition.
Osteoclastic and osteoblastic activity :
HBOT produces a bacteriostatic action on the responsible germs, modifies osteoclastic activity, optimizes antibiotic bioavailability, and enhanced local defence mechanisms; its constitute a good complementary treatment in chronic refractory osteomyelitis and osteoradionecroses.
Benefits if treated with Hyperbaric Oxygen therapy :
HBO also enhances bubble resorption and neural tissue oxygenation and reduces brain edema .Rationale for hyperbaric oxygen is compression of bubbles, relieving vascular obstruction and restoring perfusion.. HBO therapy usefulness even if delay is more than 24 hours after embolization.
Benefits if treated with Hyperbaric Oxygen therapy :
Treatment rationale is to hasten CO dissociation from hemoglobin even though COHb level has little bearing on a patient's condition or prognosis. Delay to treatment has adverse effects on recovery. HBO has been shown to prevent CO-mediated oxidative brain injury in animals because it inhibited leukocyte adherence to the microvascular endothelium, a required step in CO pathogenesis. For CO-exposed pregnant females, there is no scientific evidence to depart from standard HBO treatment
Delayed neurologic syndrome (DNS) defined as development of new symptoms after oxygen treatment plus deterioration on one or more subtests of a standardized neuropsychologic screening battery given to 60 of the patients.
HBO decreased the incidence of DNS after CO poisoning. DNS after CO poisoning cannot be predicted based on patient clinical history or CO level.
The physiological benefits of hyperbaric oxygen therapy (HBOT) are: improvement of oxygenation and hastened COHb dissociation, restoration of mitochondrial function, and inhibition of adherence of leukocytes to the microvascular endothelium.
Benefits if treated with Hyperbaric Oxygen therapy :
HBOT inhibits wound infection by helping to support the body´s infection fighting white blood cells and by helping to increase the effectiveness of any antibiotics that are used when an infection occurs. HBOT aids the survival of skin graft and flaps when it is necessary to use them in more severe burns.
HBOT improve distal microvascular perfusion either during or after prolonged global ischemia, may reduce the need for surgical intervention and shorten the time of hospitalization.
Benefits if treated with Hyperbaric Oxygen therapy :
Decreased inflow into tissues and edema.
Leukocyte adherence and vasoconstriction (of arterioles adjacent to ischemic venules) are major events in reperfusion injury in muscle, and HBO appears to provide protection by minimizing these effects.
Benefits if treated with Hyperbaric Oxygen therapy :
Increased oxygen gradient between wound and surrounding environment.
HBOT Inhibits growth of anaerobic or micro-aerophilic antibiotic organisms, enhances neutrophil function compromised by hypoxia, and increases the efficacy of certain antibiotics (particularly those requiring oxygen dependent intracellular transport). Once spread of the necrotic process has been halted, HBOT may promote healing by stimulating angiogenesis and granulation tissue formation, as in other conditions.
Benefits if treated with Hyperbaric Oxygen therapy :
The physiological benefits of HBOT are improved oxygenation of threatened margins of wounds, generation of granulation tissue, enhanced phagocytosis and killing of select organisms, enhanced antibiotic penetration of some organisms by antibiotics whose trans-membrane transport is oxygen-dependent, and improved wound healing with increased rate of fibroblast collagen production to support capillary angiogenesis. The direct bacteriostatic effect.
Benefits if treated with Hyperbaric Oxygen therapy :
Increased fibroblast proliferation leading to increased collagen deposition and increased fibronectin, which aids in neovascularization .
HBOT ameliorates the hypoxia, post-operative swelling, and ischemia of grafts and flaps. HBOT provides high concentrations of oxygen to the graft bed so that more oxygen can diffuse into the graft to sustain it during an ischemic period. The anti-edema effect of HBOT improves tissue oxygenation by reducing the distance oxygen must diffuse, and by improving perfusion.
The Benefit of HBOT for the preparation of a base for skin grafting and the preservation of compromised skin grafts has been well documented
Radiation tissue damage and Osteoradionecrosis prophylaxis
Benefits if treated with Hyperbaric Oxygen therapy :
Increased oxygen gradient between wound and surrounding environment
Increased fibroblast proliferation leading to increased collagen deposition and increased fibronectin.
Hyperbaric oxygen therapy may be able to improve oxygenation and induce angiogenesis in damaged organs, resulting in recovery from radiation injury.
Hyperbaric oxygen therapy to be a significant weapon in the armamentarium for treatment of hematuria secondary to radiation-induced injury to the bladder.
HBO to prevent the development of osteoradionecrosis after tooth removal and the loss of titanium implants in irradiated facial bones.
The physiologic basis of HBO can be referred to induction of neoangiogenesis and revascularization.
Benefits if treated with Hyperbaric Oxygen therapy :
Decreased clostridial alpha toxins.
The greatest benefit of HBO is achieved when regional blood flow is intact but local injury and infection have diminished nutrition and oxygen supply to the locally infected tissue. Leucocyte oxidative killing increases oxygen free radicals.
Benefits if treated with Hyperbaric Oxygen therapy :
HBOT antibiotic synergy Fluoroquinolones, amphotericin B, and aminoglycosides Use oxygen to transport across cell membranas, Incresead oxygen free radicals.
The greatest benefit of HBO is achieved when regional blood flow is intact but local injury and infection have diminished nutrition and oxygen supply to the locally infected tissue.
Benefits if treated with Hyperbaric Oxygen therapy :
Hyperbaric oxygen (HBO) efficiently increases the diffusional driving force for oxygen, thereby increasing tissue oxygen availability. This overcomes ischemia/hypoxia and so reduces cerebral edema, restores integrity to the blood/brain barrier and cell membranes, neutralizes toxic amines, promotes phagocytosis, scavenges free radicals, stimulates angiogenesis, and reactivates idling neurons.
Benefits if treated with Hyperbaric Oxygen therapy :
HBOT reduces edema, and causes the in-growth of new capillaries into fibrotic or scarred areas. HBOT improves the ability of the host to fight infection by directly killing anaerobic bacteria (which comprise 15 percent of all isolates from chronic osteomyelitis); enhancing neutrophil functioning for the destruction of aerobic organisms; and improving the transport of commonly used antibiotics, such as the aminoglycosides, across the bacterial cell wall. Increased oxygen free radicals
Benefits if treated with Hyperbaric Oxygen therapy :
Blood loss in which blood products are refused for religious reasons or in cases of severe hemolysis or a rare blood type for which no adequate cross-match may be obtained, HBOT can provide temporary support of tissue oxygenation. The patient must be given supplemental epoetin, iron, folate, and nandrolone decanoate to maximize marrow production. Enough O2 can be physically dissolved in plasma at 3 atm abs to support life, and inhibition of erythropoiesis is not apparent with -intermittent use of HBO.